was presented on the South Carolina Nutrition Summit Poster Presentation (Oct
17, 2003; the poster #41).
Phytochemisrty and Nutritions in Ukraine
Dr. S. Dzyubak,
Dr. A. Ulesov
Scientific Center of Medicinal Substances,Kharkov, Ukraine
phone: (757)-989-1962 (USA)
The plants are a unique depository of vitally important bio-active compounds
which are completely compatible with human organisms. For this reason, in many
cases the herbal remedies are more preferable versus synthetic ones. What is
more, in some cases they are the only ones which could be used. In this talk,
the results of studies and development of herbal remedies and nutritions are
presented. Studies and development have been done at National Scientific Center
of Medicinal Substances, Kharkov, Ukraine.
The plants are a unique depository of vitally important bio-active compounds
which are completely compatible with human organisms. In contrast to synthetic
medicines, herbal remedies made from plants have less toxicity and small
allergic effect. For this reason, in many cases the herbal remedies are more
preferable versus synthetic ones. What is more, in some cases they are the only
ones which could be used.
The State Pharmacopeia in Russia and Ukraine includes both
synthetic medicine and plenty of medical herbs, herbal extracts, purified herbal
I have worked in "the Laboratory of investigation of
phytopharmaceutical products" of the most famous and oldest pharmaceutical
Institution in Ukraine, the National Scientific Center of Medicinal Substances (NSCMS,
Kharkov, Ukraine), which has over 85 years experience in developing both
synthetic and herbal medicines. In NSCMS more than 40% of Ukraine's stock-list
medicine have been invented. The mainstream of Center's work is focused on a
study of natural substances and medicinal plants. Based on those studies, a lot
of new herbal remedies and nutritions (bio-active supplements or dietary
supplements) were created. The NSCMS can make a complete set of medicine
investigations. That includes as follows.
1)Investigation of natural substances and their pharmacological effects.
2)Elaboration of technological processes for pharmaceutical manufactures on the
base of GMPs.
3)Development of pharmaceutical analysis.
4)Elaboration technical and technological documentation.
In the Center a lot of medicines for treatment and
prophylaxis of diseases of heart, kidney, GI track, liver, etc. have been
developed. Most of those medicines have been accepted by the State Pharmacopeia
for medicinal practice. Among created medicines, I would like to mention the
1) The cardiotonic medicines based on Foxglove (Latin name Digitalis lanata).
a) Natural complexes of cardiac glycosides such as Digoxinum,
Digitoxinum, Celanidum, and Lanatosidum (Latin names).
b) Semi-synthetic glycoside (Latin name Medilasidum) which
are obtained by methylating of digoxin.
2) The choleretic medicine Flacuminum (Latin name) which is a natural complex
of flavonoid's aglicons extracted from the leaves of Smoke-trees (Latin name
3) Both anti-inflammatory and anti-ulcer medicine
extracted from the roots of Elecampane (Latin name Inula helenium).
4)The nephrolithiasis medicine Marelinum (Latin name) which includes the
extracts of Madder (Latin name Rubia tinctorum), Field-Horsetail (Latin name
Equisetum arvense), Goldenrod (Latin name Solidago canadensis), Ammi visnaga
(Latin name), Lily-of-the-valley (Latin name Convallaria majalis) and
In addition to the drastic medicines, it has also been
created preventive medicines which are closer to nutritions. They are medicines
with mild laxative effect. As an example, I would like to mention
Laminarinum (Latin name) extracted from Sea-Kale, (Latin name Laminaria).
Cafiolum which contains leaves and fruits of Senna (Latin name Cassia
acutifolia), pulp of fruits of Plums (Latin name Prunus domestica) and Fig tree
(Latin name Ficus carica), and liquid petrolatum.
The anti-ulcer remedy has also been developed on the base of
Chamomile (Latin name Matricaria chamomille) and the Japanese-pagoda-tree (Latin
name Sophora japonica).
Studies of herbal medicines are still in progress. In recent
years, we have focused on developing Bio-active Supplements (BAS or BS). The
definition Bio-active supplement could be used as an equivalent to nutritions.
As an example, I would like to mention Siberian cedar and Sea-buckthorn.
Siberian cedar's (Latin name Pinus sibirica) nuts is an
essential food product and natural source of Cedar Oil. In terms of calories,
nutrient index and digestibility coefficient, Cedar nuts exceed meat, bread,
eggs, cream, etc. For normal functions, human organisms need macro- and
micro-elements which participate in biochemical processes. In Cedar nuts the
content of such elements is very high. That makes the Siberian cedar's nutmeat
an unique source of mineral substances. Since the old days, the people of
Siberia have used the cedar nuts as medicine for treating different diseases
such as tophus, gastrointestinal tract disfunction, liver disease, gallbladder
The cedar nuts are also used as a source of a high quality
oil, the Cedar Oil. Cedar oil has widely been used as folk medicine. It has
excellent organoleptic properties and unique content of bio-active compounds.
Cedar oil can be use as an excellent treatment for tuberculosis,
atherosclerosis, hight blood pressure.
After the cedar oil extracted, the cedar nut's waste still
keeps an active protein-carbohydrate complex. For this reason, our laboratory
has prepared a project to develop new nutritions based on utilizing the cedar
nut's waste in combination with various herbal extracts, for instance, Flaxseed
(Latin name Radiola), Sea-Buckthorn (Latin name Hippophae rhamnoides), Balm (Latin
name Melissa), Sage (Latin name Salvia), ect.
On the basis of the defatted waste products of cedar's nuts
it has been proposed a new group of nutritions for treating and preventing
various disease. At present those new nutritions have only preliminary names
such as Cedar #.
Cedar 1 could be used for preventive measures against flu
or cold-disease. It contains an ascorbic acid and extracts of Flaxseed (Latin
name Radiola rosea), Magnolia-vine (Latin name Schizandra chinensis),
Eleutherococcus senticosus (Latin name), Ginseng (Latin name Panax ginseng).
Cedar 2 could be used for preventive measures against GI
tract diseases. It contains extracts of Lemon-Balm (Latin name Melissa
officinalis), Sage (Latin name Salvia officinalis), Nettle (Latin name Urtica
Cedar 3 could be used for preventive measures against
cardiovascular diseases. It contains extracts of Valeriana (Latin name Valeriana
officinalis), Redhaw Hawthorn (Latin name Crataegus sanguinea), Common Balm (Latin
name Melissa officinalis).
Cedar 4 could be used for preventive measures against
neuropathy and nervosism which contains extracts of Hop (Latin name Humulus
lupulus), Balm (Latin name Melissa), Allheal (Latin name Valeriana officinalis),
Cardiac Motherwort (Latin name Leonurus cardiaca).
Cedar 5 is bio-active nutrient consisting of a large
protide group. This nutrient can be used under conditions when one has an
intensive physical activity.
Another amazing plant which is used for production of
nutritions is Sea-Buckthorn. At all the times, Sea-Buckthorn (Latin name
Hippophae rhamnoides) has been used for production of the sea-buckthorn's oil (brown
oil). This oil contains a big amount of carotinoids and other lipids. In
addition to lipid fraction, Sea-Buckthorn has vitamins, pectins, micro- and
macro-elements. Seeds of sea-buckthorn contain so called "white" oil. These oils
have a different fatty acid content. In recent years, we have used all
substances of this plant for developing new nutritions.
In our Lab (Laboratory of investigation phytopharmaceutical
products) we conduct a study and development of nutritions which have a large
variety of pharmacological effects. The main idea which leads us is an idea of
complex treatment of the human organism. We see the general scenario as follows.
1)As a first step, a patient takes nutritions which are able to clean up the
entire human body from toxic compounds.
2)After that, one can use nutritions which are able to affect some specific
human's body systems or organs (directed medicinal effect).
3)After human body got stabilized, one can use health-improving nutritions
(health care nutritions).
I have briefly described the directions of work of my institute and laboratory
in the field of health care. Unfortunately, the Ukrainian economy is going down
resulting the lack of funds for science. However, National Scientific Center of
Medicinal Substances still has a very high scientific potential.
We know that the United States pays close attention to the development and use
of nutritions. My colleagues and I are very interested in a sort of
"International Collaborations" at any level, "person-to-person" or
"Institute-to-Institute". We still have a lot of ideas which could be realized
Thanks all of you for your attention.